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KMID : 0351219920240020107
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Korean Journal of Infectious Diseases
1992 Volume.24 No. 2 p.107 ~ p.113
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Haemophilus influenzae Isolated from Sputum Specimens : Prevalence, Biotypes and Antimicrobial Susceptibility
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정윤섭
송경순/배직현/김의종/최태열
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Abstract
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Haemophilus influenzae, one of the normal flora of upper respiratory tract, may cause various infections. In this study, sputum specimens, taken mostly from eldery inpatients at 5 university hospitals in Seoul, during the August 1991 to January
1992
were cultured on vancomycin-bacitracin-clindamycin agar and 8.3% yielded H. influenzae. Among the isolates were: biotype I 41%; serotype b 4 (1.4%) serotype a and c-f 3 (1.0%); β-lactamase producer 30.6%. Agar dilution test was performed with
52β-lactamase-negative (HB-) and 31 β-lactamase positive (HIB+) isolates. The ranges of minimum inhibitory concentration (MIC, in㎍/ml) against HIB-/HIB+ were: ampicillin 0.25-1/4->128; cefaclor 0.5-8/1-16; cefadroxil 4-128/4-128; cephalexin
2-32/2-64; cephalothin 0.25-16/0.25-16; cephradine 4-64/4-128; erythromycin 1-32/2-32; tetracycline 0.25-16/0.25-32. Application of the breakpoints to the agar dilution test results showed that all of the HIB- were susceptible to ampicillin and
cefaclor. All of the HIB+ were resistant to ampicillin, but 97% were susceptible to cefaclor. In conclusion, β-lactamase-positive strains became more frequently isolated, and both HIB+ and HIB- are often resistant to cefadroxil, cephalexin,
cephradine
and erythromycin, but mostly susceptible to cefaclor.
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KEYWORD
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